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A possible mechanism of action for PFAS is generating oxidative stress, which severely damages DNA [259]
Decline of NAD+ with Age & Cellular Metabolism Verdin E
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In a study of CSF NfL levels in a longitudinal multicenter cohort, patients with PSP and MSA had higher levels of CSF NfL than the PD group, whereas the control group had lower levels of NfL ( An accurate assessment of the amount of elevated NfL in CSF may be hampered by the fact that CSF NfL may also increase with age due to degenerative changes in axons, even though its elevated levels correspond with the severity of cognitive impairment in patients ( 3.2 Neurotransmitter-related biomarkers In general, patients with PD have degeneration of dopaminergic neurons in the SN compacta, decreased dopamine levels in striatal areas, and decreased levels of the dopamine metabolites homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC)
