Participants characteristics are reported in Table 1
What they found: 4,192 human genes change expression by 2 in response to GHK-Cu (31.2 % of the human genome) Of these 2,296 genes up-regulated , 1,896 down-regulated Pattern of changes: a rejuvenating signature, genes typically associated with ageing are down-regulated, regenerative genes up-regulated DNA repair , strong up-regulation of genes in BER, HR, NER pathways Mitochondrial biogenesis , increase in the number of mitochondria in cells Anti-apoptotic signal , protection against cell death Down-regulation of cancer signals , some oncogenes decreased Why it matters: This is the strongest evidence for the pleiotropic nature of GHK-Cu
33 van Soest EM, Dieleman JP, Siersema PD, Sturkenboom MC, Kuipers EJ
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Another benefit of serum glutathione is that it reduces oxidative damage caused by the body's exposure to stress, toxins, aging, and other environmental factors
ACE2 is expressed in most human tissues and cell types as a type I integral membrane protein solubilized by the action of a disintegrin and metallopeptidase (ADAM)-17 293
