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Sirtuins are involved in regulation of metabolism, stress response and aging (Michan and Sinclair, 2007)

Chihara, K., et al (2006)

Given the absence of long-term human trial data, conservative use under clinical supervision is the standard position among practitioners who take the evidence seriously

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Dizziness or Fatigue : A few individuals experience dizziness or general fatigue after starting therapy, likely due to the body adjusting to the peptide

These discoveries have given rise to the idea that bipolar disorder is a bioenergetic and metabolic disease with psychiatric manifestations, and that disruptions in the molecular and cellular signalling networks that regulate brain energy metabolism in a biphasic manner are a primary, sufficient cause of bipolar disorder-related phenomena [189]