The certainty of evidence was rated using the Grading of Recommendations Assessment, Development, and Evaluation approach, and risk of bias was assessed using Cochrane tool
2 Molecular mechanisms of ferroptosis Ferroptosis, a novel form of cell death distinct from apoptosis, pyroptosis and autophagy, is an iron-dependent programmed form of cell death characterized by an iron metabolism disorder, imbalance of the redox system and the accumulation of lipid peroxides (6, 7)
The new research, published on-line in the journal Clinical Nutrition, divided 60 male albino Wistar rats into 10 groups, depending on age (young, middle-aged, or old) and supplementation with placebo (saline solution), L-carnitine only (300 mg per kg body weight per day), alpha-lipoic acid (100 mg per kg body weight per day), or both
This highlights the importance of using appropriate controls (such as counter-screens) and applying PAINS filters during drug discovery efforts to avoid being misled by artifacts
Ghersi-Egea et al
Oancea 2021 )
