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Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Stevenson and Thornton, 2007)

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Research areas include: .Matrix metalloproteinases (MMPs) .Tissue inhibitors of metalloproteinases (TIMPs) .Connective tissue organization .Protein turnover .Matrix homeostasis These studies help researchers better understand how tissues adapt, remodel, and maintain structural integrity

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