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Several factors can lead to elevated B12 levels, including: Over-supplementation: The excessive intake of vitamin B12 through high-dose oral supplements or repeated intramuscular injections can raise blood levels of B12 temporarily 6

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209 For instance, Liu et al found that lncRNA-CIR can inhibit the expression of MMP-13 and ADAMTS-5, while promoting the synthesis of type I and II collagen and proteoglycans, ultimately mitigating cartilage degradation in OA