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20% of NB patients and drives half of the aggressive forms of the disease with poor outcomes ( MYCN transcriptional machinery, synthetic lethality, and destabilization of the MYCN protein ( NB, like other malignancies, is associated with modifications in cellular metabolism that may contribute to oncogenesis

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The reduction of MYCN protein levels in MYCN-driven brain tumors is of major importance due to its central role as an oncogenic driver (71)

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