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Under this definition, both retatrutide and GHK-Cu when used for systemic or therapeutic purposes are likely to fall within the scope of medicines regulation, even if marketed as 'research chemicals' or 'cosmetic peptides' (MHRA: Guidance on borderline products)

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The recommended use is 1 capsule daily, preferably on an empty stomach

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It has been suggested that loop diuretics might contribute to insulin resistance in the liver (Schliess et al., 2001) and as such contribute to increased hepatic gluconeogenesis, while thiazides may exacerbate insulin resistance in general (Ramsay et al., 1992