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Forward genetic screens in mice uncover mediators and suppressors of metastatic reactivation

Reactive oxygen species (ROS)/reactive nitrogen species (RNS) are general terms involving both oxygen/nitrogen-based free radicals and nonradical oxidant species derived from oxygen/nitrogen

For this reason, we prefer to define this disease as Recurrent Intrahepatic Cholestasis (RIC) rather than a form of benign cholestasis (BRIC) in this review, given the possible risk of progression over the years

doi: 10.1002/cmdc.202200583 240 LincoffAMTardifJCSchwartzGGNichollsSJRydnLNealBet al

This therapy is commonly used to support metabolic efficiency and overall vitality

These trials show good safety and moderate efficacy (Hafez Ghoran et al., 2022)