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Protection of glucotoxicity by a tripeptide derivative of -melanocyte-stimulating hormone in human epidermal keratinocytes

315,316,317,318 In AD, enhanced activity of L-type VGCCs, potentially related to their interaction with A/tau, promotes excessive calcium influx into cells

The compound incorporates three non-standard structural features: an -aminoisobutyric acid (Aib) at the N-terminus bearing no stereocenter, a D-2-naphthylalanine (D-2-Nal) at position 3, and a D-phenylalanine at position 4

These indicate that oral L-carnitine for more than 14 days impairs spermatogenesis in mice, and sudden discontinuation of administration results in substantial death of established spermatogenic cell populations

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