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These findings provide a robust methodological platform for tobacco research as well as mechanistic insights into how prolonged smoke exposure promotes epithelial adaptation, revealing NRF2-dependent resilience as a crucial early marker in smoking-related lung cancer development

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These proposed actions included bringing forward legislation raising the age of sale of tobacco by one year every year, making it an offence to sell tobacco products to anyone born on or after 1 January 2009, as well as increasing funding for stop smoking services and quit campaigns