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Furthermore, the circadian dysfunction in the Tg2576 model has been associated with compromised GABAergic signaling in the suprachiasmatic nucleus (SCN), a critical structure for orchestrating circadian rhythms ( Synaptic dysfunction underlying NPS in AD Synaptic dysfunction, a hallmark of AD, plays a crucial role in the NPS observed in various AD models, including 3xTg, APP/PS1, and hAPP J20 models

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