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While smoking a cigarette, nicotine reaches the brain within 10 to 20 s and binds to acetylcholine receptors (nACHRs), which subsequently leads to the release of various neurotransmitters such as dopamine, noradrenaline, serotonin and -endorphin (Yildiz 2004

1 The schematic mechanisms of E-cigarettes (E-cig) that promotes breast cancer (BC) growth and lung metastasis

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