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Glucuronidation Increases BUT Is Insufficient While glucuronidation (the other safe pathway) does increase during pregnancy: This increase in glucuronidation CANNOT compensate for the simultaneous: 33% decrease in sulfation (another safe pathway) 80% increase in oxidation to toxic NAPQI **The Result:** When both safe pathways become saturated or overwhelmed, significantly more acetaminophen is forced through the toxic CYP2E1 pathway, creating 43% more NAPQIat precisely the time when glutathione reserves are most depleted
Cell Physiol Biochem 44(2):532553
Children with chronic otitis media with effusion given glutathione as a nasal aerosol had improvement in 67% of patients, versus only 8% of controls
Statistical analysis All statistical analyses were performed by means of GraphPad Prism v
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