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ETC receives hydrogen ions from nicotinamide adenine dinucleotide (NADH) or flavin adenine dinucleotide (FADH 2 ) and deliver electrons to oxygen, ultimately generating ROS [37]

Manik and Singh, 2022)

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Tocopherol isomers, such as -, -, and -tocopherol, are commonly used as standards for lipid-soluble antioxidants, while ascorbic acid is used for water-soluble equivalents

Zhao et al., 2021a

In this hypothesis, the homozygous thermolabile MTHFR mutation would predispose to folate deficiency, which is likely to increase the cardiovascular disease risk by elevating homocysteine levels