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In murine models of SIRT5-deficient hepatocellular carcinoma, in which cholesterol levels are elevated due to the inability to convert cholesterol to bile acids, treatment with cholestyramine, a bile acid sequestrant and FDA-approved drug for hyperlipidemia, effectively inhibited the promotion of M2-type polarized TAMs (106, 110)

Therefore, inhibiting glutathione reduction phenocopies the protective effects of etomoxir

10.1101/gad.884001 Genes Dev

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Weight gain during adulthood may heighten risk, even if weight remains normal

In extreme scenarios, like those tied to iron deficiency, it may lead to further red cell damage, amplifying symptoms