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the SCCS specifically cleared retinoids up to 0.05% in body lotions and 0.3% in face creams, hand creams, and rinse-off products

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Upon activation cues, GSTO1 removes this inhibitory SSG on ASC to enable ASC speck formation and productive inflammasome assembly 68

However, when administering a lower dose of 2APB, i.e., 1 mg/kg, the protective effect on APAP tolerance was observed only in wild-type mice, for which survival rate was 100% at 60 h post-2APB administration

Without validated biomarkers of efficacy, real-world results remain anecdotal at best