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Sun M, Zhu C, Long J, Lu C, Pan X, Wu C

Since AOD-9604 failed to demonstrate efficacy as a standalone treatment, there is no scientific rationale for expecting additive benefits

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Escalating the dose to chase a faster result is explicitly not the studied approach

In response to extracellular ATP, the P2X 7 purinergic receptors may shift from rapid-gating channels selective for small cations to more slowly developing dilated pore conformations permeable to molecules up to 900 Da (North, 2002) and thus facilitate glutamate release under pathological conditions (Duan et al., 2003)