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A triple agonist activates three different receptors simultaneously
PGPIPN attenuated alcohol-intake induced hepatic lipid metabolic disturbance and oxidative stress of model animals in vivo Biochemical assays revealed higher serum TG, TC and LDL-C (low density lipoprotein-cholesterol) and liver TG (TG concentrations in liver homogenate) in the model group mice compared with control group, while serum HDL-C (high density lipoprotein-cholesterol) was lower than that in model group (Figure 6A)
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This impairment of DNA synthesis affects the rapidly dividing cells of the bone marrow earlier than other cells, resulting in the production of large, immature, hemoglobin-poor red blood cells (macrocytosis), as well as effects on white blood cells, including abnormal (hypersegmented) neutrophils and reduced overall cell counts (pancytopenia)
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