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The result is a compound with dramatically superior pharmacokinetics: once-weekly dosing and 5 the weight loss of pramlintide

NAD+ tissue uptake kinetics - IV infusion study showing delayed plasma NAD+ rise consistent with rapid tissue uptake

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IGF-1 LR3 is engineered to do the same thing, but for a much longer period of time and without being captured by the proteins that normally limit IGF-1 activity

Treatment of Parkinson 's Disease In one aspect, the HGF mimics of the invention are used to treat Parkinson's disease (PD), e.g

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