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It is very important to apply this rule only to like compounds

Mild fatigue during early titration

However, if any particulate matter remains undissolved or the solution remains cloudy, the vial should be discarded for safety

doi:10.1056/NEJMoa2107519

Additionally, the physician may also take note of the patient's medical history, including any previous surgeries, trauma, or family history of hernias, which could further inform their assessment and guide the diagnostic process