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In 1949, Linus Pauling showed that an abnormal protein (hemoglobin S, HbS) was the cause of sickle cell anemia (SCA), making SCD the first molecular disease and motivating an enormous amount of scientific and medical research

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This process of combining a sterile diluent with a lyophilized peptide is called reconstitution, and it converts a stable powder into a liquid that can be measured and injected accurately

4 to 5 kcal per mole), when several such bonds exist the resulting structure can be quite robust

They are based on the latest medical knowledge and advice from experts around the world

Sahbaz, J.M