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These findings suggest that DMF, in addition to NRF2 activation on antioxidant response, could affect L2HGDH expression, L2HG and SAM levels to modify DNA 5mC and 5hmC modifications and CBS expression in SCD erythroblasts

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Therefore, the development of an epigenetic diet used to neutralize epigenomic aberrations might pave the way toward an innovative approach to improve fertility rates and female reproductive health (162)