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The transforming growth factor- (TGF-)TGF- receptor 2 (TGFR2) signaling pathway regulates differentiation, maturation, proliferation, migration, and attachment of both ECs and pericytes [78, 79]

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Moreover, AhR can also contribute to the preservation of the gut epithelial layer of the intestine by stimulating the AhR-Nrf2 pathway or increasing the production of gut-tight junction proteins including ZO-1 and Occludin[54], [55]

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By nurturing a healthy gut, BPC-157 can contribute to better digestion, increased vitality, and improved overall health

As we move forward, personalizing microbiome therapies will likely be necessary for instance, stratifying patients by their microbiome profile or metabolite levels, then tailoring the intervention (one patient might need more SCFAs, another needs more anti-TMAO measures, etc.)