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JMF4073 eliminates WT-Bcr-Abl-transformed myeloid cells in vitro and in vivo Since the balanced supply of dNTPs is critical for overcoming DNA damage and replication stress for cell survival, we then tested whether JMF4073 treatment could selectively suppress the growth of Bcr-Abl-transformed but not untransformed myeloid cells

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These hybrids exhibited superior neuroprotective effects and lower cytotoxicity compared with curcumin alone, activated ARE, chelated ferrous ions and scavenged ROS, thereby protecting cells from oxidative stress and ferroptosis, ultimately promoting neuronal survival (104,127,128)

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Isoforms of tau (3-repeat and 4-repeat) help distinguish between disorders such as progressive supranuclear palsy, corticobasal degeneration, and Picks disease, while -synuclein pathology supports the diagnosis of PD and dementia with Lewy bodies (DLB) [542]

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