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Cystinosin-LKG, the alternatively spliced isoform of cystinosin, has a broader localization that could be leveraged to reduce cystine accumulation, restore lysosomal function, and lower apoptosis rates in cystinotic proximal tubule cells [155]

In this case, the UPR can activate apoptotic signalling pathways that lead to cell death [45, 46]

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The first one that we commonly see is vitamin D supplementation