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All patients received supportive treatment with supplemental oxygen and corticosteroids

Cotreatment with TNBS and cigarette smoke exacerbated these effects, leading to increased weight loss, elevated DAI scores, shortened colon length, additional tissue and mucosal damage evident from histopathological analysis, and increased murine endoscopic index of colitis severity (MEICS) (Fig

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It reduces the oxygen-carrying capacity of red blood cells, causing damage to the body, particularly the cardiovascular system

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