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This finding highlights not only the key role that mitochondrial metabolism has in modulating response and resistance to TS inhibitors, but the wider opportunity afforded to enhance TS inhibitor-mediated anti-cancer effects by targeting mitochondrial metabolism using metformin or other compounds with similar mitochondrial impact

Co-Evolution-Based Prediction of Metal-Binding Sites in Proteomes by Machine Learning

doi:10.1016/j.envint.2016.08.019 Dzhambov AM

Cell Signaling Cat# 23214) incubation was carried out overnight at 4 C

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From homeostasis to neuroinflammation: insights into cellular and molecular interactions and network dynamics