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This injury may represent an early event that initiates glomerulosclerosis during hyperhomocysteinemia

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Am J Transl Res 10(1):4053 Ma W et al (2019) PQQ ameliorates skeletal muscle atrophy, mitophagy and fiber type transition induced by denervation via inhibition of the inflammatory signaling pathways

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When these signals exceed the detoxification capacity of the liver, they may spill over into the systemic circulation, thereby propagating pathological cascades to peripheral organs