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In cells from older donors, this treatment partly restored cellular responses to a younger level

These hits were further analyzed using in vitro assays, eventually leading us to a primary lead, juglone

We may produce a ton of it, but we also do a lot of things that cancel it out: eating poorly, spending time in highly polluted areas, or taking too many medications

doi: 10.1083/jcb.201604085 47 MeftahA.HasegawaH.KantrowitzJ

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These include serious allergic reactions, potential liver and kidney damage, and, in some cases, even life-threatening complicationsespecially when administered without proper medical supervision or outside of clinical environments