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Refrigeration at 28 C is appropriate once the working timeline extends past a month

doi:10.1016/j.heliyon.2022.e11624

Nature , 530(7589), 184-189

guidance for repeated-entry vials points to a 28-day window unless the label states another period, and that opened-vial window cannot go past the original expiration date

ICV is used to represent Virchows triadhypercoagulability, heamodynamic changes and endothelial injury/dysfunctionand represents a subset of deep vein thrombosis (DVT)