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In 2021, Jung et al., in Korea, investigated whether the oral intake of enzymatically decomposed collagen peptides (acid-processed collagen peptides [APCPs]: 1000 mg suspended in 25-mL samples administered once per day) could improve skin moisture and barrier function by assessing changes in the ceramide and natural moisturizing factor (NMF) contents in the stratum corneum (SC), comparing baseline parameters to end-of-treatment parameter values [37]

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S4), which connects the active with the C-terminal domain

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