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(i) over dependence of few herbicide groups results in rapid evolution and spread of resistance (ii) lacking of diversified management practices make it more complex (iii) multiple resistance mechanism of weeds (iv) timely adoption of weed management strategies are difficult due to the lack of knowledge about evolution of resistance (v) high cost of integrated management approaches (vi) poor implementation of resistance-avoidance strategies, (vii) the scarcity of herbicides with new mechanisms of action, (viii) The absence of a decision support system to manage the weeds, (ix) the persistent seed bank of HR weeds remains viable for many years in soil, (x) the regulatory barriers against the introduction of new herbicide molecules in the market [11, 85,86,87,88]

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In addition, IL-23 sustains Th17 lineage and IL-17 production while also inducing GM-CSF secretion from Th17 cells

Glutathione is the liver's major antioxidant, often depleted in fatty liver disease due to oxidative stress and inflammation

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