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It is caused by either lack of intrinsic factors or surgical removal of parts of the digestive system that bypass the small intestine

An exemplary case of MRTX849, a covalent inhibitor targeting KRAS G12C mutant, benefited from a lower reactivity warhead with an additional fluorine at the acrylamide -carbon position, thus achieving better metabolic stability [113]

Those with a severe deficiency may require a 5000 mcg dose

[DOI] [PubMed] [Google Scholar] 8.Baynes R., Riviere J

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Surgical margins and risk of local recurrence after wedge resection of colorectal pulmonary metastases