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Champlin R, Khouri I, Shimoni A, Gajewski J, Kornblau S, Molldrem J, Ueno N, Giralt S, Anderlini P

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The activation of PI3K/AKT signaling, downstream from the insulin/IGF-1 receptors, stimulates the activity of mTOR which in turn is a potent inhibitor of autophagy (Fig

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