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Mechanism of telomere shortening by oxidative stress

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CoQ 10 oxidoreductases in the regulation of ferroptosis (1) FSP1 in the regulation of ferroptosis FSP1 as a therapeutic target in cancer FSP1 (formerly AIFM2) was first identified as a ferroptosis regulator among CoQ 10 oxidoreductases through independent unbiased genetic screens conducted by the Conrad and Olzmann groups under conditions of GPX4 inhibition 16,17

These proteins regulate iron influx and efflux to maintain redox balance (249)