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Preferential induction of apoptosis by interferon (IFN)- compared with IFN-2: correlation with TRAIL/Apo2L induction in melanoma cell lines

Therapy mimics this effect for sustainable benefits

A lower ratio indicates more oxidative stress

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HSPA5, heat shock protein family A (Hsp70) Member 5

Effective treatment begins with early nonpharmacologic measures such as physiotherapy, occupational therapy, and psychological support, followed by cautious introduction of pharmacologic options such as gabapentinoids, SNRIs, TCAs, and NAC based on patient response and tolerance level