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PLA-based scaffolds have shown excellent mechanical properties for musculoskeletal applications, offering tunable degradation rates suitable for regenerative strategies [146]

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When Phase 1 activity exceeds Phase 2 capacity, reactive intermediate metabolites may accumulate faster than they can be neutralized

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[DOI] [PubMed] [Google Scholar] 48.Matsumaru K, Ji C, Kaplowitz N: Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes