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Diacetyl, a chemical which is used as a butter substitute in flavours like Cotton Candy and Cupcake, has been linked to respiratory disease bronchiolitis obliterans Although it is thought to be safe when eaten, the United States National Institute for Occupational Safety and Health has said it could be hazardous when inhaled over a long period

[56] Flavors such as chocolate, caramel, mint, menthol, coffee, cherry, and apple can be added to the liquid nicotine

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Moreover, it was suggested that it is unlikely that a response to a repeated fear ad remains static [20]