Patients with this type of bile acid diarrhea have significantly lower FGF19 and higher 7a-hydroxy-4-cholesten-3-one (C4) levels than healthy controls (169), which supports the hypothesis that excess synthesis of bile acids may overflow the reabsorption capacity in the ileum and hence allow bile acids to enter the colon in larger quantities
Another piece of evidence of a link between microbiota perturbations and endometriosis is that certain medications (treatment with letrozole, the Traditional Chinese Medicine Shaofu Zhuyu decoction 72 , or antibiotics 73 ) reduced endometriotic implant volumes in rats and mice, and was thought to be due in part to restoration of the gut microbiota
Introducing changes one at a time provides clearer feedback
While early research and anecdotal evidence are promising, regulatory warnings and limited human trials mean caution is necessary
In contrast to most modalities that have their effect globally with some immune system level change and/or change in more global control of hormonal function, BPC 157 is thought to work locally as a dressing in the injury itself through a number of different potential mechanisms: inducing angiogenesis (new blood vessel formation), reducing inflammation, and inducing development of new tissue
Steelant B, Wawrzyniak P, Martens K, Jonckheere AC, Pugin B, Schrijvers R, Bullens DM, Vanoirbeek JA, Krawczyk K, Dreher A, Akdis CA, Hellings PW
