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Compared to untreated patients, pancreatic cancer patients resistant to chemotherapy exhibited high levels of iCAFs in tumour stroma, indicating a role of iCAFs in chemoresistance [235]

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Moreover, in these sporadic cases of severe G6PD deficiency with CGD, PPP flux is markedly diminished to the point of impaired NADPH oxidase activity and absent NETosis (28), and the impaired phagocytic respiratory burst was clinically linked to cases of mycobacterial infection (29)

Table 5 compares the clinical characteristics of vascular and neurogenic claudication

doi: 10.2174/0115733998249061231009093006 124 SunYGuoLQWangDGXingYJBaiYPZhangTet al