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Several senolytic drugs such as gemcitabine, navitoclax, and duocarmycin analog (JHB71A) have been modified into galactose-functionalized prodrugs namely SSK1, Nav-Gal (Fig

Using human(h) or rat(r) lens epithelial cells (LECs) and aging human lenses, we showed that a progressive increase in oxidative load during aging was linked to a decline in Prdx6 expression

Apr 1 2022;105(4):397-405

Increased intracellular ROS oxidize cysteine residues on KEAP1, leading to NRF2 release and nuclear translocation [130]

I always tell my patients to set phone alarms or keep a simple notepad handy

Commercial availability would follow FDA approval, likely in early 2028