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In intracerebral hemorrhage mouse models, the normalization of tight junction proteins ZO-1 and occludin by fibroblasts has been observed to enhance BBB integrity [293]

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Theyre more effective as a pair than either one alone

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That doesnt mean its wrong the chemistry is reasonable but it does mean the 100x more potent claims you see in promotional copy are essentially marketing language layered on top of plausible but unverified pharmacokinetic logic