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Through the 1970s and 1980s, gastric-physiology research had established the concept of "cytoprotection" the observation by Andr Robert and others that certain agents could protect gastric mucosa against injury without reducing acid secretion [1]

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At the end of dosing, the ARA 290 group had improved a mean of ~19 m, while the placebo group had declined by ~15 m, about a 4% improvement and 3% decrease of baseline, respectively

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