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The L-reduced form is the biologically active one

Functionally, knockdown of GPR81 in lactate-containing low-glucose culture conditions resulted in decreased mitochondrial activity and massive death of pancreatic cancer cells

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Rodent (diet-induced obesity, 11 days) Subcutaneous 5-Amino-1MQ at roughly 34 mg/kg/day reduced body weight and white adipose mass without changing food intake or lean mass

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[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Saadat M