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Due to the limited research on human subjects, the range of possible side effects is not fully understood

[DOI] [PubMed] [Google Scholar] Yoshino J, Mills KF, Yoon MJ, Imai IS

Sirtuins: critical regulators at the crossroads between cancer and aging

For example, the GST enzymes, part of phase II detoxification, are upregulated by the Nrf2 pathway.[ref][ref] Direct antioxidant effects: In addition to activating endogenous antioxidants via the Nrf2 pathway, sulforaphane also has some direct antioxidant properties, as it can scavenge free radicals and reactive oxygen species (ROS)

Why it matters for body composition: By decreasing chronic inflammation and improving how the body handles glucose, Amlexanox creates a more favorable internal environment for fat loss and muscle gain

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