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Mechanistically, because amino acid concentrations in the intracellular fluid are generally higher than those in the extracellular fluid in mammalian cells, including humans, AATs transport amino acids through ion conjugation or amino acid exchange to produce sodium ions

Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA

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Mechanistically, HIF-1 directly bound to the promoter of the ACSL4 gene and regulated ACSL4 transcription (Fig