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Campbell concluded: The regulatory environment is changing, and anyone tracking this space needs to understand exactly what that means

10.1097/00005072-197805000-00006 2 AharonovichE.HasinD

84 A significantly higher increase in B12 levels was seen in both patients with PN and healthy volunteers with the three times per week compared with once a week administration

That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again

1 2 European Food Safety Authority (25 September 2008)

[20] Treatment of megaloblastic anemia with concurrent vitamin B 12 deficiency using B 12 vitamers (including cyanocobalamin), creates the possibility of hypokalemia due to increased erythropoiesis (red blood cell production) and consequent cellular uptake of potassium upon anemia resolution