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Encephalopathy and cerebral edema in the setting of acute liver failure: pathogenesis and management

Control is achieved by a complex interplay between three principal metabolic pathways: 1

In addition, many substances such as alcohol, drugs, and various compounds can reduce glutathione levels in the body.One of the main pathways in phase II of detoxification is the conjugation with glutathione (tripeptide consisting of three amino acids - cysteine, glutamic acid, and glycine).Essentially, glutathione conjugation helps to detoxify and eliminate poisons and toxins in the liver, lungs, intestines, and kidneys

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Escherichia fergusonii interferes with host lipid metabolism by secreting microRNA-sized small RNAs that inhibit hepatic lipid -oxidation and promote liver fat accumulation [64]

Gut 70 , 698706 (2021)