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The first concept is known as the sequential concept, which suggests that CSD, manifested as aura, promotes the dilation of intracranial blood vessels and neurogenic inflammation, leading to the development of migraine headache [29]

doi: 10.3389/fphys.2025.1497566 46 ZhangYZhangWZhaoYPengRZhangZXuZet al

Finally human clinical studies that measure TMAO, track cardiovascular endpoints, and examine microbiome interactions with L-carnitine will better define clinical relevance

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